Journal article
Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation
Abstract
OBJECTIVE: To investigate the impact of a prolonged and constant active TGF-beta expression by the synovial lining cells on cartilage and ligamentous joint structures in vivo.
DESIGN: An adenoviral vector (AdTGF-beta1(223,225)) was used for the overexpression of active TGF-beta1 in knee joints of C57Bl/6 mice.
Authors
Bakker AC; van de Loo FAJ; van Beuningen HM; Sime P; van Lent PLEM; van der Kraan PM; Richards CD; van den Berg WB
Journal
Osteoarthritis and Cartilage, Vol. 9, No. 2, pp. 128–136
Publisher
Elsevier
Publication Date
February 2001
DOI
10.1053/joca.2000.0368
ISSN
1063-4584