Update on bipolar disorder biomarker candidates Academic Article uri icon

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  • Bipolar disorder is a chronic and disabling mood disorder with a complex pathophysiological basis. A significant percentage of patients do not receive correct diagnosis which directly influences therapeutic response, rendering recovery troublesome. There is a long-standing need for proper non-clinically based tools for diagnosis, treatment selection and follow-up of such patients. Areas covered: In the past decade, the scientific community has shown a great interest in biomarker development. Here, we highlight the different potential biomarkers and we discuss their feasibility and their possible clinical relevance. Expert commentary: To date, despite the major ongoing trials and consortia with promising future perspectives, no reliable biomarker of bipolar disorder has been fully defined.


  • Teixeira, Antonio L
  • Salem, Haitham
  • Frey, Benicio
  • Barbosa, Izabela G
  • Machado-Vieira, Rodrigo

publication date

  • November 1, 2016