Journal article
Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity
Abstract
PURPOSE: Evidence suggests that lean body mass (LBM) may be useful to normalize doses of chemotherapy. Data from a prospective study were used to determine if the highest doses of 5-fluorouracil (5-FU) per kilogram LBM would be associated with dose-limiting toxicity in stage II/III colon cancer patients treated with 5-FU and leucovorin.
EXPERIMENTAL DESIGN: Toxicity after cycle 1 was graded according to National Cancer Institute Common Toxicity …
Authors
Prado CMM; Baracos VE; McCargar LJ; Mourtzakis M; Mulder KE; Reiman T; Butts CA; Scarfe AG; Sawyer MB
Journal
Clinical Cancer Research, Vol. 13, No. 11, pp. 3264–3268
Publisher
American Association for Cancer Research (AACR)
Publication Date
June 1, 2007
DOI
10.1158/1078-0432.ccr-06-3067
ISSN
1078-0432