Journal article
Insulin resistance and cardiovascular outcomes in the ORIGIN trial
Abstract
AIMS: In the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial (Clinicaltrials.gov: NCT000069784), titrated doses of basal insulin glargine targeting fasting normoglycaemia had a neutral effect on cardiovascular outcomes. The dose of insulin required to achieve normoglycaemia provides a unique measurement of each individual's resistance to insulin's action, and was therefore used to examine the link between insulin …
Authors
Gerstein HC; Ferrannini E; Riddle MC; Yusuf S; Investigators OT
Journal
Diabetes Obesity and Metabolism, Vol. 20, No. 3, pp. 564–570
Publisher
Wiley
Publication Date
March 2018
DOI
10.1111/dom.13112
ISSN
1462-8902