Journal article
An msbB Homologue Carried in Plasmid pO157 Encodes an Acyltransferase Involved in Lipid A Biosynthesis in Escherichia coli O157:H7
Abstract
Escherichia coli O157:H7 carries a chromosomal msbB1 and a plasmid-encoded msbB2 gene. We characterized msbB2 function as a homologue of msbB1 by examination of wild-type organisms and mutant strains that lacked functional msbB1, msbB2, and both msbB1 and msbB2. The msbB double-mutant strain generated pentaacyl lipid A, while the single-mutant strains synthesized hexaacyl lipid A. Complementation with overexpressed msbB2 converted pentaacyl …
Authors
Kim S-H; Jia W; Bishop RE; Gyles C
Journal
Infection and Immunity, Vol. 72, No. 2, pp. 1174–1180
Publisher
American Society for Microbiology
Publication Date
2 2004
DOI
10.1128/iai.72.2.1174-1180.2004
ISSN
0019-9567