Journal article
Deterioration of polyamino acid-coated alginate microcapsules in vivo
Abstract
The implantation of immuno-isolated recombinant cell lines secreting a therapeutic protein in alginate microcapsules presents an alternative approach to gene therapy. Its clinical efficacy has recently been demonstrated in treating several genetic diseases in murine models. However, its application to humans will depend on the long-term structural stability of the microcapsules. Based on previous implantations in canines, it appears that …
Authors
van Raamsdonk JM; Cornelius RM; Brash JL; Chang PL
Journal
Journal of Biomaterials Science Polymer Edition, Vol. 13, No. 8, pp. 863–884
Publisher
Taylor & Francis
Publication Date
1 2002
DOI
10.1163/156856202320401933
ISSN
0920-5063