Journal article
Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity
Abstract
The orexin-2/hypocretin-2 (OX2R) receptor gene is mutated in canine narcolepsy and disruption of the prepro-orexin/hypocretin ligand gene results in both an animal model of narcolepsy and sporadic cases of the human disease. This evidence suggests that the structure of the OX2R gene, and its homologue, the OX1R gene, both members of the G protein-coupled receptor (GPCR) family, and the gene encoding the peptide ligands, the …
Authors
Thompson MD; Comings DE; Abu‐Ghazalah R; Jereseh Y; Lin L; Wade J; Sakurai T; Tokita S; Yoshida T; Tanaka H
Journal
American Journal of Medical Genetics Part B Neuropsychiatric Genetics, Vol. 129B, No. 1, pp. 69–75
Publisher
Wiley
Publication Date
August 15, 2004
DOI
10.1002/ajmg.b.30047
ISSN
1552-4841
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnimalsCOS CellsCalciumChlorocebus aethiopsComorbidityDNADNA Mutational AnalysisDisorders of Excessive SomnolenceDose-Response Relationship, DrugHumansIntracellular Signaling Peptides and ProteinsIntracellular SpaceMutationMutation, MissenseNeuropeptidesOrexin ReceptorsOrexinsPolymorphism, Single-Stranded ConformationalReceptors, G-Protein-CoupledReceptors, NeuropeptideTourette Syndrome