Journal article
Total Synthesis of (±)-Mersicarpine
Abstract
The first total synthesis of the indole alkaloid mersicarpine is reported. Key steps include a beta-dicarbonyl radical cyclization, as well as an oxidation of the benzopyrrole moiety to establish the masked 1,2-dicarbonyl functionality. An X-ray crystal structure and discussion of the 1H NMR behavior of the natural product are also presented.
Authors
Magolan J; Carson CA; Kerr MA
Journal
Organic Letters, Vol. 10, No. 7, pp. 1437–1440
Publisher
American Chemical Society (ACS)
Publication Date
April 1, 2008
DOI
10.1021/ol800259s
ISSN
1523-7060