Journal article
sli-3 Negatively Regulates the LET-23/Epidermal Growth Factor Receptor-Mediated Vulval Induction Pathway in Caenorhabditis elegans
Abstract
The LIN-3-LET-23-mediated inductive signaling pathway plays a major role during vulval development in C. elegans. Studies on the components of this pathway have revealed positive as well as negative regulators that function to modulate the strength and specificity of the signal transduction cascade. We have carried out genetic screens to identify new regulators of this pathway by screening for suppressors of lin-3 vulvaless phenotype. The …
Authors
Gupta BP; Liu J; Hwang BJ; Moghal N; Sternberg PW
Journal
Genetics, Vol. 174, No. 3, pp. 1315–1326
Publisher
Oxford University Press (OUP)
Publication Date
November 1, 2006
DOI
10.1534/genetics.106.063990
ISSN
0016-6731
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AllelesAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell LineageChromosome MappingEmbryo, NonmammalianEmbryonic InductionEpistasis, GeneticErbB ReceptorsEthyl MethanesulfonateFemaleGene Expression Regulation, DevelopmentalGenes, HelminthGenetic MarkersHelminth ProteinsMutagenesisMutagensVulva