E-cadherin core fucosylation regulates nuclear β-catenin accumulation in lung cancer cells

E-cadherin expressed highly in 95C and lowly in 95D lung cancer cells which were from the same patient, but core-fucosylated E-cadherin highly expressed in 95D cells. Therefore, Fut8 and Fut8-RNAi constructs were transfected into 95C and 95D cells, respectively. In Fut8-transfectants, reduction of nuclear β-catenin was noted when E-cadherin was core-fucosylated, while accumulation of nuclear β-catenin was observed in Fut8-RNAi transfectants. In …