Wei Deng - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Member, Peter Boris Centre for Addictions Research (PBCAR), Faculty of Health Sciences
Assistant Professor (Part-Time), Psychiatry & Behavioural Neurosciences, Faculty of Health Sciences

Research Areas

Addiction (RA)
Data visualization (RA)
Epigenetics and epigenomics (RA)
Genomics (RA)
High dimensional data analysis (RA)
Statistical methods for high throughput data (RA)

Scholarly Activity in McMaster Experts

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selected scholarly activity

conferences
- Contribution of rare coding variants to complex trait heritability. Genetic Epidemiology. 523-523. 2022
- A HIGH-RESOLUTION PHEW AS APPROACH TO ELUCIDATE FUNCTIONAL INFLUENCES OF ALCOHOL-IMPLICATED VARIANTS FROM LARGE-SCALE GWAS. Alcoholism: Clinical and Experimental Research. 200A-200A. 2022
- Less is More: An Unbiased and Versatile Estimator of Genetic Variance Using Summary Statistics. Genetic Epidemiology. 752-753. 2021
- Novel method to estimate regional genetic associations improves genetic scores performance. Genetic Epidemiology. 573-574. 2015
- A Maximum Likelihood Approach to Prioritize SNPs for Interactions Using Variance per Genotype. Genetic Epidemiology. 754-754. 2012
- Prioritizing SNPs for Gene-Environment and Gene-Gene Interactions: A method to Meta-analyze Levene's Test of Homogeneity of Variance. Genetic Epidemiology. 757-758. 2012
- A Maximum Likelihood Approach to Prioritize SNPs for Interactions Using Variance per Genotype. Genetic Epidemiology. 141-142. 2012
journal articles
- Mitochondrial DNA Copy Number Is Associated with Incident AKI, CKD, and Inflammatory Biomarkers. Journal of the American Society of Nephrology. 35:10.1681/asn.202421s12k91. 2024
- Longitudinal characterization of impulsivity phenotypes boosts signal for genomic correlates and heritability.. Molecular Psychiatry. 2024
- Consistent cord blood DNA methylation signatures of gestational age between South Asian and white European cohorts. Clinical Epigenetics. 16:74. 2024
- A method to estimate the contribution of rare coding variants to complex trait heritability. Nature Communications. 15:1245. 2024
- A high-resolution PheWAS approach to alcohol-related polygenic risk scores reveals mechanistic influences of alcohol reinforcing value and drinking motives. Alcohol and Alcoholism. 59:agad093. 2024
- Leveraging related health phenotypes for polygenic prediction of impulsive choice, impulsive action, and impulsive personality traits in 1534 European ancestry community adults. Genes, Brain and Behavior. 22:e12848. 2023
- Exploring dimension learning via a penalized probabilistic principal component analysis. Journal of Statistical Computation and Simulation. 93:266-297. 2023
- gJLS2: an R package for generalized joint location and scale analysis in X-inclusive genome-wide association studies. G3: Genes, Genomes, Genetics. 12:jkac049. 2022
- gJLS2: An R package for generalized joint location and scale analysis in X-inclusive genome-wide association studies 2021
- Mitochondrial DNA Genetic Variants in the Risk for Schizophrenia. Biological Psychiatry. 89:S4-S4. 2021
- Author Correction: A machine-learning heuristic to improve gene score prediction of polygenic traits. Scientific Reports. 9:17507. 2019
- Analytical strategies to include the X‐chromosome in variance heterogeneity analyses: Evidence for trait‐specific polygenic variance structure. Genetic Epidemiology. 43:815-830. 2019
- A robust method to estimate regional polygenic correlation under misspecified linkage disequilibrium structure. Genetic Epidemiology. 42:636-647. 2018
- A machine-learning heuristic to improve gene score prediction of polygenic traits. Scientific Reports. 7:12665. 2017
- Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLoS Genetics. 13:e1006812-e1006812. 2017
- A method to estimate the contribution of regional genetic associations to complex traits from summary association statistics. Scientific Reports. 6:27644. 2016
- Contribution of Large Region Joint Associations to Complex Traits Genetics. PLoS Genetics. 11:e1005103-e1005103. 2015
- Response to Letter Regarding Article “Temporal Relationship Between Subclinical Atrial Fibrillation and Embolic Events”. Circulation. 131:e337-e338. 2015
- Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?. Diabetologia. 57:2270-2281. 2014
- Temporal Relationship Between Subclinical Atrial Fibrillation and Embolic Events. Circulation. 129:2094-2099. 2014
- Meta-analysis of SNPs involved in variance heterogeneity using Levene’s test for equal variances. European Journal of Human Genetics. 22:427-430. 2014
- Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort. Genetical Research. 93:419-426. 2011
- A fast algorithm to optimize SNP prioritization for gene-gene and gene-environment interactions. Genetic Epidemiology. 35:729-738. 2011
- Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry. eLife. 13.
preprints