Journal article
A method to estimate the contribution of regional genetic associations to complex traits from summary association statistics
Abstract
Despite considerable efforts, known genetic associations only explain a small fraction of predicted heritability. Regional associations combine information from multiple contiguous genetic variants and can improve variance explained at established association loci. However, regional associations are not easily amenable to estimation using summary association statistics because of sensitivity to linkage disequilibrium (LD). We now propose a …
Authors
Pare G; Mao S; Deng WQ
Journal
Scientific Reports, Vol. 6, No. 1,
Publisher
Springer Nature
DOI
10.1038/srep27644
ISSN
2045-2322