selected scholarly activity
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books
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chapters
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conferences
- The polyfunctionality of memory CD8+ T cells in response to chronic and acute viral infections is not influenced by age (105.49). Journal of Immunology. 105.49-105.49. 2012
- Analysis of Sus scrofa liver proteome with isotope tagging for relative and absolute quantification (iTRAQ).. Canadian Journal of Animal Science. 164-164. 2009
- Association of Toll-like receptor 4 polymorphisms with Johne's disease.. Canadian Journal of Animal Science. 166-167. 2009
- Association of single nucleotide polymorphisms in the interleukin-12 receptor beta-2 gene with Johne's disease and production traits in dairy cattle.. Canadian Journal of Animal Science. 154-154. 2009
- Identification of single nucleotide polymorphisms in bovine peptidoglycan recognition protein 1 and their association with inflammatory disease resistance in Canadian dairy cattle.. Canadian Journal of Animal Science. 157-158. 2009
- Single nucleotide polymorphisms (SNPs) in bovine IL-10, IL-10 receptor, and TGF-beta, and their association with milk somatic cell score and susceptibility, to Mycobacterium avium paratuberculosis (MAP) infection.. Canadian Journal of Animal Science. 155-155. 2009
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journal articles
- Omission of alcohol skin cleansing and risk of adverse events in long-term care residents undergoing COVID-19 vaccination: A cohort study. Human Vaccines and Immunotherapeutics. 20:2368681. 2024
- Defining an ageing-related pathology, disease or syndrome: International Consensus Statement.. GeroScience. 1-8. 2024
- Emergency Department Boarding Time Is Associated with Functional Decline in Older Adults Six Months Post Discharge.. Canadian Journal on Aging. 1-9. 2024
- Salivary DNA methylation derived estimates of biological aging, cellular frequency and protein expression as predictors of oral mucositis severity and survival in head and neck cancer patients.. Oral Oncology. 159:107030. 2024
- Predicting major clinical events among Canadian adults with laboratory-confirmed influenza infection using the influenza severity scale.. Scientific Reports. 14:18378. 2024
- A systematic review and meta‐analysis of oncological outcomes with transanal total mesorectal excision for rectal cancer. Colorectal Disease. 26:837-850. 2024
- Age- and sex-specific associations of frailty with mortality and healthcare utilization in community-dwelling adults from Ontario, Canada. BMC Geriatrics. 24:223. 2024
- Burnout among public health workers in Canada: a cross-sectional study. BMC Public Health. 24:48. 2024
- Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species. Cells. 12:2655-2655. 2023
- Metabolic signature for a dysbiotic microbiome in the female genital tract: A systematic review and meta‐analysis. Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy. 90:e13781. 2023
- Antibody-mediated NK cell activation as a correlate of immunity against influenza infection. Nature Communications. 14:5170. 2023
- A DNA methylation based measure outperforms circulating CRP as a marker of chronic inflammation and partly reflects the monocytic response to long‐term inflammatory exposure: A Canadian Longitudinal Study on Aging analysis. Aging Cell. 22:e13863. 2023
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Response to Raj et al Abdominoperineal resection by trans‐anal
TME approach: are we refuting the technology a bit too early?. Colorectal Disease. 25:1538-1539. 2023 - Protection from Omicron Infection in Residents of Nursing and Retirement Homes in Ontario, Canada. Journal of the American Medical Directors Association. 24:753-758. 2023
- Protection from Omicron Infection in Residents of Nursing and Retirement Homes in Ontario, Canada. Journal of the American Medical Directors Association. 24:753-758. 2023
- The Association Between Shift Work Exposure and Frailty Among Middle-Aged and Older Adults. Journal of Occupational and Environmental Medicine. 65:355-361. 2023
- Parsing chronological and biological age effects on vaccine responses. Aging. 15:1235-1236. 2023
- COVID-19 vaccination delivery in long-term-care using the CARD (Comfort Ask Relax Distract) system: Mixed methods study of implementation drivers. Canadian Journal of Pain. 6:173-184. 2022
- LAMP3/CD63 Expression in Early and Late Endosomes in Human Vaginal Epithelial Cells Is Associated with Enhancement of HSV-2 Infection. Journal of Virology. 96:e0155322. 2022
- Likelihood of hospitalization for a chronic respiratory condition following pediatric infection with enterovirus and rhinovirus strains. Infectious Medicine. 1:245-252. 2022
- Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells. Immunity and Ageing. 19:26. 2022
- Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination. Journal of Immunology. 209:1892-1905. 2022
- Activity-related dyspnea in older adults participating in the Canadian Longitudinal Study on Aging. Journal of General Internal Medicine. 37:3302-3309. 2022
- Adjuvant-attenuated symptom severity of influenza infections in vaccinated children. Infectious Medicine. 1:163-170. 2022
- Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons. Immunity and Ageing. 19:39. 2022
- Associations between exposure to adverse childhood experiences and biological aging: Evidence from the Canadian Longitudinal Study on Aging. Psychoneuroendocrinology. 142:105821-105821. 2022
- Natural immunity helps overcome the age-related decline of SARS-CoV-2 vaccine immunogenicity. The Lancet Healthy Longevity. 3:e449-e450. 2022
- Transanal total mesorectal excision for abdominoperineal resection is associated with poor oncological outcomes in rectal cancer patients: A word of caution from a multicentric Canadian cohort study. Colorectal Disease. 24:380-387. 2022
- Cohort profile: genomic data for 26 622 individuals from the Canadian Longitudinal Study on Aging (CLSA). BMJ Open. 12:e059021-e059021. 2022
- Associations of Adverse Childhood Experiences with Frailty in Older Adults: A Cross-Sectional Analysis of Data from the Canadian Longitudinal Study on Aging. Gerontology. 68:1091-1100. 2022
- Estimating SARS-CoV-2 seroprevalence in long-term care: a window of opportunity. The Lancet Healthy Longevity. 3:e2-e3. 2022
- Infectious diseases, comorbidities and outcomes in hospitalized people who inject drugs (PWID). PLoS ONE. 17:e0266663-e0266663. 2022
- NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults. Frontiers in Aging. 3:1098200. 2022
- Clustering of obesity-related characteristics: A latent class analysis from the Canadian Longitudinal Study on Aging. Preventive Medicine. 153:106739-106739. 2021
- Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging. Clinical Epigenetics. 13:163. 2021
- Respiratory Symptoms Are Associated With Frailty in Older Adults With Normal Spirometry, Independent of Smoking, in the Canadian Longitudinal Study of Aging. Respiratory Care. 66:1848-1857. 2021
- Antibody Responses 3-5 Months Post-Vaccination with mRNA-1273 or BNT163b2 in Nursing Home Residents 2021
- The frequency of interleukin-1β-producing monocytes is significantly associated with varicella-zoster responses of nursing home residents. Clinical and Experimental Immunology. 205:63-74. 2021
- Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults. Frontiers in Aging. 2:649110. 2021
- Exploring the perioperative outcomes of a sample of successful adopters of transanal total mesorectal excision (taTME) during the learning phase. Surgery. 169:774-781. 2021
- MDSCs, ageing and inflammageing. Cellular Immunology. 362:104297-104297. 2021
- Depot medroxyprogesterone acetate (DMPA) enhances susceptibility and increases the window of vulnerability to HIV-1 in humanized mice. Scientific Reports. 11:3894. 2021
- Association of Transanal Total Mesorectal Excision With Local Recurrence of Rectal Cancer. JAMA network open. 4:e2036330-e2036330. 2021
- Transcriptional response of vaginal epithelial cells to medroxyprogesterone acetate treatment results in decreased barrier integrity. Journal of Reproductive Immunology. 143:103253-103253. 2021
- Comparing Biological Age Estimates Using Domain-Specific Measures From the Canadian Longitudinal Study on Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 76:187-194. 2021
- Antibody and Cell-Mediated Immune Responses Are Correlates of Protection against Influenza Infection in Vaccinated Older Adults. Vaccines. 9:25-25. 2021
- A Snapshot of the International Views of the Treatment of Rectal Cancer Patients, a Multi‐regional Survey: International Tendencies in Rectal Cancer. World Journal of Surgery. 45:302-312. 2021
- Comparing ‘Twitter’ polls results with an online survey on surgeons perspectives for the treatment of rectal cancer. BMJ Innovations. 7:192-198. 2021
- Corrigendum: Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults. Frontiers in Aging. 2:718966. 2021
- Granzyme B: A Double-Edged Sword in the Response to Influenza Infection in Vaccinated Older Adults. Frontiers in Aging. 2:753767. 2021
- Modifiable factors related to life-space mobility in community-dwelling older adults: results from the Canadian Longitudinal Study on Aging. BMC Geriatrics. 20:35. 2020
- Reliable reference genes for the quantification of mRNA in human T-cells and PBMCs stimulated with live influenza virus. BMC Immunology. 21:4. 2020
- The immune response to influenza in older humans: beyond immune senescence. Immunity and Ageing. 17:10. 2020
- Factors affecting stability of plasma brain-derived neurotrophic factor. Scientific Reports. 10:20232. 2020
- A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging. Respiratory Medicine. 173:106157-106157. 2020
- Expression profiling of human milk derived exosomal microRNAs and their targets in HIV-1 infected mothers. Scientific Reports. 10:12931. 2020
- Frailty Is Associated With Increased Hemagglutination-Inhibition Titers in a 4-Year Randomized Trial Comparing Standard- and High-Dose Influenza Vaccination. Open Forum Infectious Diseases. 7:ofaa148. 2020
- Oral Health, Diet, and Frailty at Baseline of the Canadian Longitudinal Study on Aging. Journal of The American Geriatrics Society. 68:959-966. 2020
- Experience beyond the learning curve of transanal total mesorectal excision (taTME) and its effect on the incidence of anastomotic leak. Techniques in Coloproctology. 24:309-316. 2020
- Non-HDL cholesterol level and depression among Canadian elderly—a cross-sectional analysis of the baseline data from the CLSA. Facets. 5:1006-1018. 2020
- Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer. Frontiers in Immunology. 11:369. 2020
- Zoster Vaccination in Older Adults: Efficacy and Public Health Implications. The journals of gerontology. Series A, Biological sciences and medical sciences. 74:1239-1243. 2019
- Atomic resolution map of the soluble amyloid beta assembly toxic surfaces. Chemical Science. 10:6072-6082. 2019
- Examining the Association between Life-Space Mobility and Cognitive Function in Older Adults: A Systematic Review. Journal of Aging Research. 2019:1-9. 2019
- Frailty Is Inversely Related to Age at Menopause and Elevated in Women Who Have Had a Hysterectomy: An Analysis of the Canadian Longitudinal Study on Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 74:675-682. 2019
- Frailty Is Inversely Related to Age at Menopause and Elevated in Women Who Have Had a Hysterectomy: An Analysis of the Canadian Longitudinal Study on Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 74:749-749. 2019
- Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity. Frontiers in Immunology. 10:1099. 2019
- PROCEEDINGS OF THE CANADIAN FRAILTY NETWORK WORKSHOP: IDENTIFYING BIOMARKERS OF FRAILTY TO SUPPORT FRAILTY RISK ASSESSMENT, DIAGNOSIS AND PROGNOSIS. TORONTO, JANUARY 15, 2018. Journal of Frailty and Aging. 8:1-11. 2019
- Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study. Respiratory Research. 19:245. 2018
- A comprehensive assessment of immunophenotyping performed in cryopreserved peripheral whole blood. Cytometry Part B - Clinical Cytometry. 94:818-826. 2018
- Cryopreserved whole blood for the quantification of monocyte, T‐cell and NK‐cell subsets, and monocyte receptor expression by multi‐color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. Cytometry Part B - Clinical Cytometry. 93:548-555. 2018
- DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly. Experimental Gerontology. 105:47-52. 2018
- Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host and Microbe. 23:570-570. 2018
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Transcriptional profiling of primary endometrial epithelial cells following acute
HIV ‐1 exposure reveals gene signatures related to innate immunity. Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy. 79:e12822. 2018 -
Medroxyprogesterone acetate‐treated human, primary endometrial epithelial cells reveal unique gene expression signature linked to innate immunity and
HIV ‐1 susceptibility. Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy. 79. 2018 - The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study. BMC Genomic Data. 18:57. 2017
- Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice. Scientific Reports. 7:15263. 2017
- Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents. Journal of Infectious Diseases. 216:191-197. 2017
- Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host and Microbe. 21:455-466.e4. 2017
- The Molecular Structure of Human Red Blood Cell Membranes from Highly Oriented, Solid Supported Multi-Lamellar Membranes. Scientific Reports. 7:39661. 2017
- Immunogenicity of Varicella Vaccine and Immunologic Predictors of Response in a Cohort of Elderly Nursing Home Residents. Journal of Infectious Diseases. 214:1905-1910. 2016
- Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial. Trials. 17:377. 2016
- Mycoplasma pneumoniae , a trigger for Weston Hurst syndrome. Neurology: Neuroimmunology and NeuroInflammation. 3:e187. 2016
- Correction: Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children. PLoS ONE. 11:e0163830-e0163830. 2016
- TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. PLoS Pathogens. 12:e1005368-e1005368. 2016
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Association of
TLR 4 polymorphisms with Mycobacterium avium subspecies paratuberculosis infection status in Canadian Holsteins. Animal Genetics. 46:560-565. 2015 - Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly. Molecular Immunology. 65:148-156. 2015
- Circulating Muramyl Dipeptide Is Negatively Associated with Interleukin-10 in the Frail Elderly. Inflammation. 38:272-277. 2015
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Latent
TGF ‐β1 is Compartmentalized Between Blood and Seminal Plasma ofHIV ‐Positive Men and Its Activation in Semen is Negatively Correlated with Viral Load and Immune Activation. Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy. 73:151-161. 2015 - A macrophage-stimulating compound from a screen of microbial natural products. Journal of Antibiotics. 68:40-46. 2015
- An Introduction to Automated Flow Cytometry Gating Tools and Their Implementation. Frontiers in Immunology. 6:380. 2015
- Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children. PLoS ONE. 10:e0131531-e0131531. 2015
- Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling. Human Immunology. 75:1192-1196. 2014
- Host cytokine responses distinguish invasive from airway isolates of the Streptococcusmilleri/anginosis group. BMC Infectious Diseases. 14:498. 2014
- Immunosenescence in the nursing home elderly. BMC Geriatrics. 14:50. 2014
- MicroRNA-155 Is Required for Clearance of Streptococcus pneumoniae from the Nasopharynx. Infection and Immunity. 82:4824-4833. 2014
- Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. Journal of Experimental Medicine (JEM). 211:1657-1672. 2014
- The Loss of Topography in the Microbial Communities of the Upper Respiratory Tract in the Elderly. Annals of the American Thoracic Society. 11:513-521. 2014
- Bovine CLEC7A genetic variants and their association with seropositivity in Johne's disease ELISA. Gene. 537:302-307. 2014
- Characterization of Inflammatory Responses During Intranasal Colonization with <em>Streptococcus pneumoniae</em>. Journal of Visualized Experiments. e50490. 2014
- Alterations to the Frequency and Function of Peripheral Blood Monocytes and Associations with Chronic Disease in the Advanced-Age, Frail Elderly. PLoS ONE. 9:e104522-e104522. 2014
- Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers. Cancer & Metabolism. 1:17. 2013
- Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus. Cell Chemical Biology. 20:1168-1178. 2013
- Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer. Journal of Leukocyte Biology. 93:633-637. 2013
- Proteomic analysis of plasma from Holstein cows testing positive for mycobacterium avium subsp. Paratuberculosis (MAP). Veterinary Immunology and Immunopathology. 148:243-251. 2012
- The Macrophage. Methods in molecular biology (Clifton, N.J.). 844:139-156. 2012
- The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by Age. PLoS Pathogens. 8:e1003076-e1003076. 2012
- Use of Breed-Specific Single Nucleotide Polymorphisms to Discriminate Between Holstein and Jersey Dairy Cattle Breeds. Animal Biotechnology. 23:1-10. 2012
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S
hort Communication : Associations of BoLA alleles DRB3.2*16 and DRB3.2*23 with health-related traits in Holstein bulls. Canadian Journal of Animal Science. 91:597-600. 2011 - Bovine IFNGR2, IL12RB1, IL12RB2, and IL23R polymorphisms and MAP infection status. Mammalian Genome. 22:583-588. 2011
- Bovine PGLYRP1 polymorphisms and their association with resistance to Mycobacterium avium ssp. paratuberculosis. Animal Genetics. 42:354-360. 2011
- Single Nucleotide Polymorphisms Alter the Promoter Activity of Bovine MIF. Animal Biotechnology. 22:143-150. 2011
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Identification of SNP
s in Interferon Gamma, Interleukin-22, and Their Receptors and Associations with Health and Production-Related Traits in Canadian Holstein Bulls. Animal Biotechnology. 22:7-15. 2011 - Polymorphisms in the gene encoding bovine interleukin-10 receptor alpha are associated with Mycobacterium avium ssp. paratuberculosis infection status. BMC Genomic Data. 11:23. 2010
- Ets-1 Regulates Energy Metabolism in Cancer Cells. PLoS ONE. 5:e13565-e13565. 2010
- Identification of single nucleotide polymorphisms in the bovine interleukin-12 and interleukin-23 receptor genes and their associations with health and production traits in Holstein cows. Journal of Dairy Science (JDS). 93:4860-4871. 2010
- Gene expression profiling of PBMCs from Holstein and Jersey cows sub-clinically infected with Mycobacterium avium ssp. paratuberculosis. Veterinary Immunology and Immunopathology. 137:1-11. 2010
- Abstract 43: Role of Ets-1 in the regulation of energy metabolism in cancer cells. Cancer Research. 70:43-43. 2010
- A principal component regression based genome wide analysis approach reveals the presence of a novel QTL on BTA7 for MAP resistance in holstein cattle. Genomics. 95:176-182. 2010
- Application of iTRAQ to catalogue the skeletal muscle proteome in pigs and assessment of effects of gender and diet dephytinization. Proteomics. 9:4000-4016. 2009
- SNPs in the bovine IL-10 receptor are associated with somatic cell score in Canadian dairy bulls. Mammalian Genome. 20:447-454. 2009
- The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. Science. 324:522-528. 2009
- Analysis of Sus scrofa liver proteome and identification of proteins differentially expressed between genders, and conventional and genetically enhanced lines. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 3:234-242. 2008
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preprints
- Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement. 2024
- Protection from Omicron infection in residents of nursing and retirement homes in Ontario, Canada 2022
- CMV seropositivity in older adults changes the T cell repertoire, but does not prevent antibody or cellular responses to SARS-CoV-2 vaccination 2022