selected scholarly activity
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books
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chapters
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conferences
- The polyfunctionality of memory CD8+ T cells in response to chronic and acute viral infections is not influenced by age (105.49). Journal of Immunology. 105.49-105.49. 2012
- Analysis of Sus scrofa liver proteome with isotope tagging for relative and absolute quantification (iTRAQ).. Canadian Journal of Animal Science. 164-164. 2009
- Association of Toll-like receptor 4 polymorphisms with Johne's disease.. Canadian Journal of Animal Science. 166-167. 2009
- Association of single nucleotide polymorphisms in the interleukin-12 receptor beta-2 gene with Johne's disease and production traits in dairy cattle.. Canadian Journal of Animal Science. 154-154. 2009
- Identification of single nucleotide polymorphisms in bovine peptidoglycan recognition protein 1 and their association with inflammatory disease resistance in Canadian dairy cattle.. Canadian Journal of Animal Science. 157-158. 2009
- Single nucleotide polymorphisms (SNPs) in bovine IL-10, IL-10 receptor, and TGF-beta, and their association with milk somatic cell score and susceptibility, to Mycobacterium avium paratuberculosis (MAP) infection.. Canadian Journal of Animal Science. 155-155. 2009
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journal articles
- Omission of alcohol skin cleansing and risk of adverse events in long-term care residents undergoing COVID-19 vaccination: A cohort study. Human Vaccines and Immunotherapeutics. 20:2368681. 2024
- Salivary DNA methylation derived estimates of biological aging, cellular frequency and protein expression as predictors of oral mucositis severity and survival in head and neck cancer patients.. Oral Oncology. 159:107030. 2024
- Defining an ageing-related pathology, disease or syndrome: International Consensus Statement.. GeroScience. 1-8. 2024
- Emergency Department Boarding Time Is Associated with Functional Decline in Older Adults Six Months Post Discharge.. Canadian Journal on Aging. 1-9. 2024
- Predicting major clinical events among Canadian adults with laboratory-confirmed influenza infection using the influenza severity scale.. Scientific Reports. 14:18378. 2024
- A systematic review and meta‐analysis of oncological outcomes with transanal total mesorectal excision for rectal cancer. Colorectal Disease. 26:837-850. 2024
- Age- and sex-specific associations of frailty with mortality and healthcare utilization in community-dwelling adults from Ontario, Canada. BMC Geriatrics. 24:223. 2024
- Burnout among public health workers in Canada: a cross-sectional study. BMC International Health and Human Rights. 24:48. 2024
- Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species. Cells. 12:2655-2655. 2023
- Metabolic signature for a dysbiotic microbiome in the female genital tract: A systematic review and meta‐analysis. American Journal of Reproductive Immunology. 90:e13781. 2023
- Antibody-mediated NK cell activation as a correlate of immunity against influenza infection. Nature Communications. 14:5170. 2023
- A DNA methylation based measure outperforms circulating CRP as a marker of chronic inflammation and partly reflects the monocytic response to long‐term inflammatory exposure: A Canadian Longitudinal Study on Aging analysis. Aging Cell. 22:e13863. 2023
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Response to Raj et al Abdominoperineal resection by trans‐anal
TME approach: are we refuting the technology a bit too early?. Colorectal Disease. 25:1538-1539. 2023 - Protection from Omicron Infection in Residents of Nursing and Retirement Homes in Ontario, Canada. Journal of the American Medical Directors Association. 24:753-758. 2023
- Protection from Omicron Infection in Residents of Nursing and Retirement Homes in Ontario, Canada. Journal of the American Medical Directors Association. 24:753-758. 2023
- The Association Between Shift Work Exposure and Frailty Among Middle-Aged and Older Adults. Journal of Occupational and Environmental Medicine. 65:355-361. 2023
- Parsing chronological and biological age effects on vaccine responses. Aging. 15:1235-1236. 2023
- COVID-19 vaccination delivery in long-term-care using the CARD (Comfort Ask Relax Distract) system: Mixed methods study of implementation drivers. Canadian Journal of Pain. 6:173-184. 2022
- LAMP3/CD63 Expression in Early and Late Endosomes in Human Vaginal Epithelial Cells Is Associated with Enhancement of HSV-2 Infection. Journal of Virology. 96:e0155322. 2022
- Likelihood of hospitalization for a chronic respiratory condition following pediatric infection with enterovirus and rhinovirus strains. Infectious Medicine. 1:245-252. 2022
- Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells. Immunity and Ageing. 19:26. 2022
- Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination. Journal of Immunology. 209:1892-1905. 2022
- Activity-related dyspnea in older adults participating in the Canadian Longitudinal Study on Aging. Journal of General Internal Medicine. 37:3302-3309. 2022
- Adjuvant-attenuated symptom severity of influenza infections in vaccinated children. Infectious Medicine. 1:163-170. 2022
- Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons. Immunity and Ageing. 19:39. 2022
- Associations between exposure to adverse childhood experiences and biological aging: Evidence from the Canadian Longitudinal Study on Aging. Psychoneuroendocrinology. 142:105821-105821. 2022
- Natural immunity helps overcome the age-related decline of SARS-CoV-2 vaccine immunogenicity. The Lancet Healthy Longevity. 3:e449-e450. 2022
- Transanal total mesorectal excision for abdominoperineal resection is associated with poor oncological outcomes in rectal cancer patients: A word of caution from a multicentric Canadian cohort study. Colorectal Disease. 24:380-387. 2022
- Cohort profile: genomic data for 26 622 individuals from the Canadian Longitudinal Study on Aging (CLSA). BMJ Open. 12:e059021-e059021. 2022
- Associations of Adverse Childhood Experiences with Frailty in Older Adults: A Cross-Sectional Analysis of Data from the Canadian Longitudinal Study on Aging. Gerontology. 68:1091-1100. 2022
- Estimating SARS-CoV-2 seroprevalence in long-term care: a window of opportunity. The Lancet Healthy Longevity. 3:e2-e3. 2022
- Infectious diseases, comorbidities and outcomes in hospitalized people who inject drugs (PWID). PLoS ONE. 17:e0266663-e0266663. 2022
- NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults. Frontiers in Aging. 3:1098200. 2022
- Clustering of obesity-related characteristics: A latent class analysis from the Canadian Longitudinal Study on Aging. Preventive Medicine. 153:106739-106739. 2021
- Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging. Clinical Epigenetics. 13:163. 2021
- Respiratory Symptoms Are Associated With Frailty in Older Adults With Normal Spirometry, Independent of Smoking, in the Canadian Longitudinal Study of Aging. Respiratory Care. 66:1848-1857. 2021
- Antibody Responses 3-5 Months Post-Vaccination with mRNA-1273 or BNT163b2 in Nursing Home Residents 2021
- The frequency of interleukin-1β-producing monocytes is significantly associated with varicella-zoster responses of nursing home residents. Clinical and Experimental Immunology. 205:63-74. 2021
- Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults. Frontiers in Aging. 2:649110. 2021
- Exploring the perioperative outcomes of a sample of successful adopters of transanal total mesorectal excision (taTME) during the learning phase. Surgery. 169:774-781. 2021
- MDSCs, ageing and inflammageing. Cellular Immunology. 362:104297-104297. 2021
- Depot medroxyprogesterone acetate (DMPA) enhances susceptibility and increases the window of vulnerability to HIV-1 in humanized mice. Scientific Reports. 11:3894. 2021
- Association of Transanal Total Mesorectal Excision With Local Recurrence of Rectal Cancer. JAMA network open. 4:e2036330-e2036330. 2021
- Transcriptional response of vaginal epithelial cells to medroxyprogesterone acetate treatment results in decreased barrier integrity. Journal of Reproductive Immunology. 143:103253-103253. 2021
- Comparing Biological Age Estimates Using Domain-Specific Measures From the Canadian Longitudinal Study on Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 76:187-194. 2021
- Antibody and Cell-Mediated Immune Responses Are Correlates of Protection against Influenza Infection in Vaccinated Older Adults. Vaccines. 9:25-25. 2021
- A Snapshot of the International Views of the Treatment of Rectal Cancer Patients, a Multi‐regional Survey: International Tendencies in Rectal Cancer. World Journal of Surgery. 45:302-312. 2021
- Comparing ‘Twitter’ polls results with an online survey on surgeons perspectives for the treatment of rectal cancer. BMJ Innovations. 7:192-198. 2021
- Corrigendum: Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults. Frontiers in Aging. 2:718966. 2021
- Granzyme B: A Double-Edged Sword in the Response to Influenza Infection in Vaccinated Older Adults. Frontiers in Aging. 2:753767. 2021
- Modifiable factors related to life-space mobility in community-dwelling older adults: results from the Canadian Longitudinal Study on Aging. BMC Geriatrics. 20:35. 2020
- Reliable reference genes for the quantification of mRNA in human T-cells and PBMCs stimulated with live influenza virus. BMC Immunology. 21:4. 2020
- The immune response to influenza in older humans: beyond immune senescence. Immunity and Ageing. 17:10. 2020
- Factors affecting stability of plasma brain-derived neurotrophic factor. Scientific Reports. 10:20232. 2020
- A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging. Respiratory Medicine. 173:106157-106157. 2020
- Expression profiling of human milk derived exosomal microRNAs and their targets in HIV-1 infected mothers. Scientific Reports. 10:12931. 2020
- Frailty Is Associated With Increased Hemagglutination-Inhibition Titers in a 4-Year Randomized Trial Comparing Standard- and High-Dose Influenza Vaccination. Open Forum Infectious Diseases. 7:ofaa148. 2020
- Oral Health, Diet, and Frailty at Baseline of the Canadian Longitudinal Study on Aging. Journal of The American Geriatrics Society. 68:959-966. 2020
- Experience beyond the learning curve of transanal total mesorectal excision (taTME) and its effect on the incidence of anastomotic leak. Techniques in Coloproctology. 24:309-316. 2020
- Non-HDL cholesterol level and depression among Canadian elderly—a cross-sectional analysis of the baseline data from the CLSA. Facets. 5:1006-1018. 2020
- Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer. Frontiers in Immunology. 11:369. 2020
- Zoster Vaccination in Older Adults: Efficacy and Public Health Implications. The journals of gerontology. Series A, Biological sciences and medical sciences. 74:1239-1243. 2019
- Atomic resolution map of the soluble amyloid beta assembly toxic surfaces. Chemical Science. 10:6072-6082. 2019
- Examining the Association between Life-Space Mobility and Cognitive Function in Older Adults: A Systematic Review. Journal of Aging Research. 2019:1-9. 2019
- Frailty Is Inversely Related to Age at Menopause and Elevated in Women Who Have Had a Hysterectomy: An Analysis of the Canadian Longitudinal Study on Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 74:675-682. 2019
- Frailty Is Inversely Related to Age at Menopause and Elevated in Women Who Have Had a Hysterectomy: An Analysis of the Canadian Longitudinal Study on Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 74:749-749. 2019
- Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity. Frontiers in Immunology. 10:1099. 2019
- PROCEEDINGS OF THE CANADIAN FRAILTY NETWORK WORKSHOP: IDENTIFYING BIOMARKERS OF FRAILTY TO SUPPORT FRAILTY RISK ASSESSMENT, DIAGNOSIS AND PROGNOSIS. TORONTO, JANUARY 15, 2018. Journal of Frailty and Aging. 8:1-11. 2019
- Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study. Respiratory Research. 19:245. 2018
- A comprehensive assessment of immunophenotyping performed in cryopreserved peripheral whole blood. Cytometry Part B - Clinical Cytometry. 94:818-826. 2018
- Cryopreserved whole blood for the quantification of monocyte, T‐cell and NK‐cell subsets, and monocyte receptor expression by multi‐color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging. Cytometry Part B - Clinical Cytometry. 93:548-555. 2018
- DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly. Experimental Gerontology. 105:47-52. 2018
- Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host and Microbe. 23:570-570. 2018
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Transcriptional profiling of primary endometrial epithelial cells following acute
HIV ‐1 exposure reveals gene signatures related to innate immunity. American Journal of Reproductive Immunology. 79:e12822. 2018 -
Medroxyprogesterone acetate‐treated human, primary endometrial epithelial cells reveal unique gene expression signature linked to innate immunity and
HIV ‐1 susceptibility. American Journal of Reproductive Immunology. 79. 2018 - The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study. BMC Genetics. 18:57. 2017
- Frequency of Human CD45+ Target Cells is a Key Determinant of Intravaginal HIV-1 Infection in Humanized Mice. Scientific Reports. 7:15263. 2017
- Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents. Journal of Infectious Diseases. 216:191-197. 2017
- Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host and Microbe. 21:455-466.e4. 2017
- The Molecular Structure of Human Red Blood Cell Membranes from Highly Oriented, Solid Supported Multi-Lamellar Membranes. Scientific Reports. 7:39661. 2017
- Immunogenicity of Varicella Vaccine and Immunologic Predictors of Response in a Cohort of Elderly Nursing Home Residents. Journal of Infectious Diseases. 214:1905-1910. 2016
- Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial—PROSPECT: a pilot trial. Trials. 17:377. 2016
- Mycoplasma pneumoniae , a trigger for Weston Hurst syndrome. Neurology: Neuroimmunology and NeuroInflammation. 3:e187. 2016
- Correction: Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children. PLoS ONE. 11:e0163830-e0163830. 2016
- TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. PLoS Pathogens. 12:e1005368-e1005368. 2016
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Association of
TLR 4 polymorphisms with Mycobacterium avium subspecies paratuberculosis infection status in Canadian Holsteins. Animal Genetics. 46:560-565. 2015 - Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly. Molecular Immunology. 65:148-156. 2015
- Circulating Muramyl Dipeptide Is Negatively Associated with Interleukin-10 in the Frail Elderly. Inflammation. 38:272-277. 2015
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Latent
TGF ‐β1 is Compartmentalized Between Blood and Seminal Plasma ofHIV ‐Positive Men and Its Activation in Semen is Negatively Correlated with Viral Load and Immune Activation. American Journal of Reproductive Immunology. 73:151-161. 2015 - A macrophage-stimulating compound from a screen of microbial natural products. Journal of Antibiotics. 68:40-46. 2015
- An Introduction to Automated Flow Cytometry Gating Tools and Their Implementation. Frontiers in Immunology. 6:380. 2015
- Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children. PLoS ONE. 10:e0131531-e0131531. 2015
- Anti-pneumococcal deficits of monocyte-derived macrophages from the advanced-age, frail elderly and related impairments in PI3K-AKT signaling. Human Immunology. 75:1192-1196. 2014
- Host cytokine responses distinguish invasive from airway isolates of the Streptococcusmilleri/anginosis group. BMC Infectious Diseases. 14:498. 2014
- Immunosenescence in the nursing home elderly. BMC Geriatrics. 14:50. 2014
- MicroRNA-155 Is Required for Clearance of Streptococcus pneumoniae from the Nasopharynx. Infection and Immunity. 82:4824-4833. 2014
- Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. Journal of Experimental Medicine (JEM). 211:1657-1672. 2014
- The Loss of Topography in the Microbial Communities of the Upper Respiratory Tract in the Elderly. Annals of the American Thoracic Society. 11:513-521. 2014
- Bovine CLEC7A genetic variants and their association with seropositivity in Johne's disease ELISA. Gene. 537:302-307. 2014
- Characterization of Inflammatory Responses During Intranasal Colonization with <em>Streptococcus pneumoniae</em>. Journal of Visualized Experiments. e50490. 2014
- Alterations to the Frequency and Function of Peripheral Blood Monocytes and Associations with Chronic Disease in the Advanced-Age, Frail Elderly. PLoS ONE. 9:e104522-e104522. 2014
- Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers. Cancer & Metabolism. 1:17. 2013
- Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus. Cell Chemical Biology. 20:1168-1178. 2013
- Blood CD33(+)HLA-DR(−) myeloid-derived suppressor cells are increased with age and a history of cancer. Journal of Leukocyte Biology. 93:633-637. 2013
- Proteomic analysis of plasma from Holstein cows testing positive for mycobacterium avium subsp. Paratuberculosis (MAP). Veterinary Immunology and Immunopathology. 148:243-251. 2012
- The Macrophage. Methods in molecular biology (Clifton, N.J.). 844:139-156. 2012
- The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by Age. PLoS Pathogens. 8:e1003076-e1003076. 2012
- Use of Breed-Specific Single Nucleotide Polymorphisms to Discriminate Between Holstein and Jersey Dairy Cattle Breeds. Animal Biotechnology. 23:1-10. 2012
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S
hort Communication : Associations of BoLA alleles DRB3.2*16 and DRB3.2*23 with health-related traits in Holstein bulls. Canadian Journal of Animal Science. 91:597-600. 2011 - Bovine IFNGR2, IL12RB1, IL12RB2, and IL23R polymorphisms and MAP infection status. Mammalian Genome. 22:583-588. 2011
- Bovine PGLYRP1 polymorphisms and their association with resistance to Mycobacterium avium ssp. paratuberculosis. Animal Genetics. 42:354-360. 2011
- Single Nucleotide Polymorphisms Alter the Promoter Activity of Bovine MIF. Animal Biotechnology. 22:143-150. 2011
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Identification of SNP
s in Interferon Gamma, Interleukin-22, and Their Receptors and Associations with Health and Production-Related Traits in Canadian Holstein Bulls. Animal Biotechnology. 22:7-15. 2011 - Polymorphisms in the gene encoding bovine interleukin-10 receptor alpha are associated with Mycobacterium avium ssp. paratuberculosis infection status. BMC Genetics. 11:23. 2010
- Ets-1 Regulates Energy Metabolism in Cancer Cells. PLoS ONE. 5:e13565-e13565. 2010
- Identification of single nucleotide polymorphisms in the bovine interleukin-12 and interleukin-23 receptor genes and their associations with health and production traits in Holstein cows. Journal of Dairy Science (JDS). 93:4860-4871. 2010
- Gene expression profiling of PBMCs from Holstein and Jersey cows sub-clinically infected with Mycobacterium avium ssp. paratuberculosis. Veterinary Immunology and Immunopathology. 137:1-11. 2010
- Abstract 43: Role of Ets-1 in the regulation of energy metabolism in cancer cells. Cancer Research. 70:43-43. 2010
- A principal component regression based genome wide analysis approach reveals the presence of a novel QTL on BTA7 for MAP resistance in holstein cattle. Genomics. 95:176-182. 2010
- Application of iTRAQ to catalogue the skeletal muscle proteome in pigs and assessment of effects of gender and diet dephytinization. Proteomics. 9:4000-4016. 2009
- SNPs in the bovine IL-10 receptor are associated with somatic cell score in Canadian dairy bulls. Mammalian Genome. 20:447-454. 2009
- The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution. Science. 324:522-528. 2009
- Analysis of Sus scrofa liver proteome and identification of proteins differentially expressed between genders, and conventional and genetically enhanced lines. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 3:234-242. 2008
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preprints
- Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement. 2024
- Protection from Omicron infection in residents of nursing and retirement homes in Ontario, Canada 2022
- CMV seropositivity in older adults changes the T cell repertoire, but does not prevent antibody or cellular responses to SARS-CoV-2 vaccination 2022