Installing FVIII-Specific Tolerance in Hemophilia Via Engagement of the Aryl Hydrocarbon Receptor By Tryptophan Derivatives

Abstract Background: The development of inhibitors is the most serious complication a patient with hemophilia can experience on treatment with clotting factor concentrates. In a cohort of 100 severe hemophilia A patients, we have recently found that the inhibitor-positive status was associated with dysfunctional indoleamine 2,3-dioxygenase 1 (IDO1)1. The mechanisms whereby IDO1 promotes regulatory effects include production of …