The Fc gamma receptor on human placental plasma membrane. I. Studies on the binding of homologous and heterologous immunoglobulin G1.

Abstract Plasma membrane vesicles prepared from human placental syncitiotrophoblast have been shown to agglutinate IgG-sensitized red blood cells in an Fc specific manner. This agglutination could be inhibited by monomelic IgG and Fc in a dose-dependent fashion, whereas neither IgA nor IgM were inhibitory. This phenomenon formed the basis of an assay that was used to investigate the binding specificity of the Fc receptor. Experiments with human …