Journal article
Characterization of a Distinctive Motif of the Low Molecular Weight Neurotrophin Receptor that Modulates NGF‐mediated Neurite Growth
Abstract
The cytoplasmic region of the common neurotrophin receptor (p75(NGFR)) (rat, human, chick) contains a putative membrane-associating domain implicated in intracellular signalling. A peptide (R3) identical to this domain (p75(NGFR) 367-379) and various analogues of this peptide displayed circular dichroism spectra in aqueous and non-polar environments identical to the amphiphilic tetradecapeptide mastoparan (MP) and were internalized by PC12 rat …
Authors
Dostaler SM; Ross GM; Myers SM; Weaver DF; Ananthanarayanan V; Riopelle RJ
Journal
European Journal of Neuroscience, Vol. 8, No. 5, pp. 870–879
Publisher
Wiley
Publication Date
May 1996
DOI
10.1111/j.1460-9568.1996.tb01574.x
ISSN
0953-816X
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAnalysis of VarianceAnimalsCell LineageCell SurvivalChick EmbryoHumansMagnesiumMolecular Sequence DataMolecular WeightNerve Growth FactorsNeuritesNeuronsNeuropeptidesPC12 CellsProtein Structure, TertiaryRatsReceptor, Nerve Growth FactorReceptor, trkAReceptors, Nerve Growth FactorStructure-Activity RelationshipVirulence Factors, Bordetella