Journal article
Label-free detection of nucleic acid and protein microarrays by scanning Kelvin nanoprobe
Abstract
A high-resolution scanning Kelvin nanoprobe is introduced as an alternative technique to the conventional fluorescence and mass spectrometric detection methods currently employed in nucleic acid and protein microarray technology. The new instrument is capable of the highly sensitive discernment of surface biochemical events taking place at molecular level such as nucleic acid hybridization and antibody-antigen interaction. The method involves …
Authors
Thompson M; Cheran L-E; Zhang M; Chacko M; Huo H; Sadeghi S
Journal
Biosensors and Bioelectronics, Vol. 20, No. 8, pp. 1471–1481
Publisher
Elsevier
Publication Date
2 2005
DOI
10.1016/j.bios.2004.06.022
ISSN
0956-5663