Journal article
Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra
Abstract
Drugs that selectively inhibit the serotonin transporter (SERT) are widely used in the treatment of depression and anxiety disorders. These agents are associated with a range of extrapyramidal syndromes such as akathisia, dystonia, dyskinesia and parkinsonism, suggesting an effect on dopaminergic transmission. We studied the time course of changes in dopaminergic neurons in the substantia nigra (SN) after initiation of two different SERT …
Authors
Macgillivray L; Reynolds KB; Sickand M; Rosebush PI; Mazurek MF
Journal
Synapse, Vol. 65, No. 11, pp. 1166–1172
Publisher
Wiley
Publication Date
November 2011
DOI
10.1002/syn.20954
ISSN
0887-4476