Journal article
Marked suppression of stimulated gastric acid and pepsin secretion by enisoprost, a new PGE1 analogue
Abstract
The gastric antisecretory effects of three different doses of enisoprost, a new synthetic PGE1 analogue, were compared with placebo and misoprostol in 20 healthy male volunteers. Enisoprost 100, 200 and 400 micrograms all significantly (P less than 0.0001; ANOVA) suppressed histamine-stimulated acid and pepsin output when compared with placebo or misoprostol 200 micrograms. Misoprostol produced a significant decrease of stimulated acid output …
Authors
HOWDEN GW; BURGET DW; SILLETTI C; VAN EEDEN A; TOMKINS KB; HUNT RH
Journal
Alimentary Pharmacology & Therapeutics, Vol. 1, No. 4, pp. 305–313
Publisher
Wiley
Publication Date
August 1987
DOI
10.1111/j.1365-2036.1987.tb00630.x
ISSN
0269-2813