Journal article
Evidence for lack of mitochondrial DNA repair followingcis-dichlorodiammineplatinum treatment
Abstract
The purpose of this study was to determine whethercis-dichlorodiammineplatinum (cisplatin) causes mitochondrial DNA (mtDNA) damage. A specific and sensitive method for quantitation of damage to mtDNA was used, by which the physical forms of mtDNA (supercoiled, open circular and linear forms) were separated by gel electrophoresis. The DNA specificity was then obtained by hybridizing with a mtDNA probe.In vitro incubation of mtDNA with cisplatin …
Authors
Singh G; Maniccia-Bozzo E
Journal
Cancer Chemotherapy and Pharmacology, Vol. 26, No. 2, pp. 97–100
Publisher
Springer Nature
Publication Date
May 1990
DOI
10.1007/bf02897252
ISSN
0344-5704