Journal article
Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes
Abstract
The pineal product melatonin has remarkable antioxidant properties. It is secreted during darkness and plays a key role in various physiological responses including regulation of circadian rhythms, sleep homeostasis, retinal neuromodulation, and vasomotor responses. It scavenges hydroxyl, carbonate, and various organic radicals as well as a number of reactive nitrogen species. Melatonin also enhances the antioxidant potential of the cell by …
Authors
Pandi-Perumal SR; BaHammam AS; Brown GM; Spence DW; Bharti VK; Kaur C; Hardeland R; Cardinali DP
Journal
Neurotoxicity Research, Vol. 23, No. 3, pp. 267–300
Publisher
Springer Nature
Publication Date
April 2013
DOI
10.1007/s12640-012-9337-4
ISSN
1029-8428
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgingAnimalsAntioxidantsApoptosisBrain InjuriesCircadian RhythmClinical Trials as TopicDouble-Blind MethodDrug Evaluation, PreclinicalFree RadicalsHomeostasisHumansLightMelatoninMiceMice, TransgenicMitochondriaMulticenter Studies as TopicNerve Tissue ProteinsNeurodegenerative DiseasesNeuronsNeuroprotective AgentsOxidative StressPineal GlandSleep Initiation and Maintenance DisordersTryptophan