Journal article
An Approach to Assigning In Vitro Potency to Unfractionated and Low Molecular Weight Heparins Based on the Inhibition of Prothrombin Activation and Catalysis of Thrombin Inhibition
Abstract
Unfractionated and low molecular weight (LMW) heparins with good antithrombotic activity invariably catalyze thrombin inhibition and inhibit the appearance of thrombin activity in contact-activated plasma. Conversely, the antithrombotic efficacy of LMW heparins decreases as their ability to catalyze thrombin inhibition and to inhibit the appearance of thrombin activity in plasma decrease. The activated partial thromboplastin time (APTT) has …
Authors
Ofosu FA; Smith LM; Anvari N; Blajchman MA
Journal
Thrombosis and Haemostasis, Vol. 60, No. 02, pp. 193–198
Publisher
Thieme
Publication Date
1988
DOI
10.1055/s-0038-1647028
ISSN
0340-6245