Journal article
Expression of Human Factor IX by Microencapsulated Recombinant Fibroblasts
Abstract
Deficiency of clotting factor IX (FIX) causes hemophilia B in humans. We propose a novel approach to its treatment by engineering FIX-secreting cell lines suitable for implantation in different allogeneic hosts. To prevent graft rejection following implantation, the recombinant cells can be protected with biocompatible membranes that permit exit of FIX but not entry of cellular immune mediators. To explore the feasibility of this approach, we …
Authors
Liu H-W; Ofosu FA; Chang PL
Journal
Human Gene Therapy, Vol. 4, No. 3, pp. 291–301
Publisher
Mary Ann Liebert
Publication Date
6 1993
DOI
10.1089/hum.1993.4.3-291
ISSN
1043-0342