Journal article
Inhibitory and excitatory mechanisms of neurotensin action in canine intestinal circular muscle in vitro
Abstract
The effect of neurotensin on canine ileal circular muscle devoid of myenteric plexus was investigated using single and double sucrose gap techniques. Similar results were obtained with microelectrode techniques. Neurotensin caused a temperature-sensitive and dose-dependent biphasic response, an initial hyperpolarization associated with inhibition of contractile activity, followed by an excitatory phase, usually consisting of spike discharge and …
Authors
Christinck F; Daniel EE; Fox-Threlkeld JE
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 70, No. 10, pp. 1423–1431
Publisher
Canadian Science Publishing
Publication Date
October 1, 1992
DOI
10.1139/y92-200
ISSN
0008-4212