Journal article
Pharmacological role and degradation processes of neuromedin N in the gastrointestinal tract: an in vitro and in vivo study.
Abstract
Neuromedin N (NN) induced a concentration-dependent contraction (ED50 = 2.3 +/- 0.2 microM) of the isolated longitudinal smooth muscle from guinea pig ileum. This effect was drastically enhanced (ED50 = 0.06 microM) by the aminopeptidases M and B inhibitor bestatin (10 microM), which elicited a 40-fold increase in NN potency. HPLC analysis indicated that the main NN catabolite generated by membranes from guinea pig longitudinal smooth muscle …
Authors
Barelli H; Woskowska Z; Cipris S; Fox-Threlkeld JE; Daniel EE; Vincent JP; Checler F
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 275, No. 3, pp. 1300–1307
Publisher
Elsevier
Publication Date
December 1995
DOI
10.1016/s0022-3565(25)12185-x
ISSN
0022-3565