Journal article
Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury
Abstract
Profound hepatocellular injury is often a consequence of adenovirus-mediated gene therapy or acetaminophen ingestion. The aim of the present study was to examine the role of a CXC chemokine, macrophage inflammatory protein-2 (MIP-2), in the hepatotoxic response by mice infected with adenovirus and challenged with acetaminophen. CD1 mice that received a replication-defective human type 5 adenovirus vector (Ad70-3) intravenously exhibited hepatic …
Authors
Hogaboam CM; Simpson KJ; Chensue SW; Steinhauser ML; Lukacs NW; Gauldie J; Strieter RM; Kunkel SL
Journal
Gene Therapy, Vol. 6, No. 4, pp. 573–584
Publisher
Springer Nature
Publication Date
April 1, 1999
DOI
10.1038/sj.gt.3300858
ISSN
0969-7128