Severe acute respiratory syndrome coronavirus nucleocapsid protein expressed by an adenovirus vector is phosphorylated and immunogenic in mice

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV) has been identified as the aetiological agent of SARS. Thus, vaccination against SARS-CoV may represent an effective approach towards controlling SARS. The nucleocapsid (N) protein is thought to play a role in induction of cell-mediated immunity to SARS-CoV and thus it is important to characterize this protein. In the present study, an E1/partially E3-deleted, replication-defective human …

Authors

Zakhartchouk AN; Viswanathan S; Mahony JB; Gauldie J; Babiuk LA

Journal

Journal of General Virology, Vol. 86, No. 1, pp. 211–215

Publisher

Microbiology Society

Publication Date

January 1, 2005

DOI

10.1099/vir.0.80530-0

ISSN

0022-1317

Associated Experts

Jack Gauldie

Professor Emeritus, Faculty of Health Sciences

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