Journal article
Extracellular matrix microenvironment contributes actively to pulmonary fibrosis
Abstract
PURPOSE OF REVIEW: The purpose of this review is to describe the contribution of an altered, profibrotic extracellular matrix (ECM) microenvironment to pulmonary fibrosis and how it changes cell behaviour and actively drives disease progression.
RECENT FINDINGS: Idiopathic pulmonary fibrosis is a chronic and fatal disease of unknown cause. It is characterized by proliferation and accumulation of fibroblasts and myofibroblasts in clusters, …
Authors
Shimbori C; Gauldie J; Kolb M
Journal
Current Opinion in Pulmonary Medicine, Vol. 19, No. 5, pp. 446–452
Publisher
Wolters Kluwer
Publication Date
September 2013
DOI
10.1097/mcp.0b013e328363f4de
ISSN
1070-5287