Optimizing electrostatic interactions for controlling the release of proteins from anionic and cationically modified alginate

Alginate and cationically modified alginate microparticles were prepared with the goal of developing hydrogel microparticles that offer controlled release of protein drugs mainly by modification of the absolute charge of the hydrogel network. Protein loading and release studies were carried out using model proteins with different net charges (i.e. low, high, and neutral isoelectric points) covering a broad range of molecular weights. The …