Journal article
Lowering of plasma isoxicam concentrations with acetylsalicylic acid.
Abstract
The pharmacokinetics of isoxicam 200 mg administered orally in 10 healthy male volunteers was studied before and during administration of acetylsalicylic acid 3.9 g daily by mouth starting 5 days after isoxicam. There was a statistically significant decrease in plasma isoxicam concentrations, but no significant change in time to reach maximum plasma concentration or disappearance time. The mechanisms of this interaction is probably competitive …
Authors
Grace EM; Mewa AA; Sweeney GD; Rosenfeld JM; Darke AC; Buchanan WW
Journal
The Journal of Rheumatology, Vol. 13, No. 6, pp. 1119–1121
Publication Date
December 1986
ISSN
0315-162X