Journal article
Antithrombin III-beta associates more readily than antithrombin III-alpha with uninjured and de-endothelialized aortic wall in vitro and in vivo.
Abstract
The properties of two isoforms, alpha and beta, of rabbit antithrombin III (ATIII) were compared in the presence of undamaged or de-endothelialized rabbit aortic wall. Similar quantities of ATIII-alpha and ATIII-beta bound to and rapidly saturated the endothelium in vitro, but the rate of transendothelial passage of ATIII-beta exceeded that of ATIII-alpha by 22%. Furthermore, ATIII-beta was adsorbed approximately twice as rapidly as ATIII-alpha …
Authors
Witmer MR; Hatton MW
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 11, No. 3, pp. 530–539
Publisher
Wolters Kluwer
Publication Date
May 1991
DOI
10.1161/01.atv.11.3.530
ISSN
1079-5642