Journal article
Displacement of Fibrin-bound Thrombin by r-Hirudin Precludes the Use of 131l-r-Hirudin for Detecting Pulmonary Emboli in the Rabbit
Abstract
Pulmonary emboli are detectable by filling defects in the pulmonary vasculature upon pulmonary angiography. Emboli derived from venous thrombi are rich in fibrin to which thrombin remains bound. Hirudin, a specific thrombin inhibitor, binds to thrombin to yield a 1:1 stoichiometric complex. We examined whether 131I-recombinant hirudin (r-hirudin) could be used to detect pulmonary emboli in rabbits. Clots were formed by re-calcifying rabbit …
Authors
Rubens FD; Ross-Ouellet B; Dennie C; Coates G; Kinlough-Rathbone RL; Hatton MWC
Journal
Thrombosis and Haemostasis, Vol. 72, No. 02, pp. 232–238
Publisher
Thieme
Publication Date
1994
DOI
10.1055/s-0038-1648845
ISSN
0340-6245