A neural network model of hippocampal–striatal–prefrontal interactions in contextual conditioning

The hippocampus is thought to be critical for encoding contextually bound memories and setting the context for ongoing behavior. However, the mechanisms by which the hippocampal-cortical system controls behavior are poorly understood. We propose a computational model in which the hippocampus exerts contextual control over motivated behavior by gating prefrontal cortex inputs to the nucleus accumbens. The model integrates the episodic memory …