Studies into the Mechanism by Which Glycosaminoglycans Potentiate Protein C Activation by Factor Xa.

Abstract Previous studies have demonstrated that protein C (PC) can be activated by factor Xa (fXa) in a reaction that requires Ca2+ and negatively-charged phospholipid. Sulfated polysaccharides, such as heparin or dextran sulfate, have been shown to accelerate this reaction, although their mechanism of action remains elusive. To further explore this phenomenon, we first examined the effect of glycosaminoglycans of varying …