Journal article
Alternative Pathway to a Glycopeptide-Resistant Cell Wall in the Balhimycin Producer Amycolatopsis balhimycina
Abstract
Balhimycin, a vancomycin-type glycopeptide, is a lipid II targeting antibiotic produced by Amycolatopsis balhimycina. A. balhimycina has developed a self-resistance mechanism based on the synergistic action of different enzymes resulting in modified peptidoglycan. The canonical resistance mechanism against glycopeptides is the synthesis of peptidoglycan precursors ending with acyl-d-alanyl-d-lactate (d-Ala-d-Lac) rather than …
Authors
Frasch H-J; Kalan L; Kilian R; Martin T; Wright GD; Stegmann E
Journal
ACS Infectious Diseases, Vol. 1, No. 6, pp. 243–252
Publisher
American Chemical Society (ACS)
Publication Date
June 12, 2015
DOI
10.1021/acsinfecdis.5b00011
ISSN
2373-8227