Journal article
Catalytic promiscuity of glycopeptide N -methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates
Abstract
We show that two α-N-methyltransferases involved in the biosynthesis of glycopeptide antibiotics (GPAs) already recognise partly crosslinked precursor peptides of teicoplanin aglycone indicating that in vivo N-methylation can occur as an early tailoring step during GPA biosynthesis. This relaxed substrate specificity is accompanied by a remarkable promiscuity regarding the co-substrate enabling modulation of biological activity and the …
Authors
Brieke C; Yim G; Peschke M; Wright GD; Cryle MJ
Journal
Chemical Communications, Vol. 52, No. 94, pp. 13679–13682
Publisher
Royal Society of Chemistry (RSC)
Publication Date
November 17, 2016
DOI
10.1039/c6cc06975d
ISSN
1359-7345