Journal article
Urokinase has direct catalytic activity against fibrinogen and renders it less clottable by thrombin.
Abstract
Recently, we demonstrated that tissue plasminogen activator directly releases fibrinopeptides A and B (FPA and FPB) from fibrinogen. The purpose of this study was to determine whether urokinase has similar activity. Incubation of urokinase with fibrinogen or heparinized plasma results in concentration-dependent FPB release unaccompanied by FPA cleavage. For equivalent amidolytic activity, high molecular weight urokinase releases twofold more …
Authors
Weitz JI; Leslie B
Journal
Journal of Clinical Investigation, Vol. 86, No. 1, pp. 203–212
Publisher
American Society for Clinical Investigation
Publication Date
July 1, 1990
DOI
10.1172/jci114685
ISSN
0021-9738