Journal article
Role of α-Helical Coiled-coil Interactions in Receptor Dimerization, Signaling, and Adaptation during Bacterial Chemotaxis*
Abstract
The aspartate receptor, Tar, is a member of a large family of signal transducing membrane receptors that interact with CheA and CheW proteins to mediate the chemotactic responses of bacteria. A highly conserved cytoplasmic region, the signaling domain, is flanked by two sequences, methylated helices 1 and 2 (MH1 and MH2), that are predicted to form alpha-helical coiled-coils. MH1 and MH2 contain glutamine and glutamate residues that are subject …
Authors
Surette MG; Stock JB
Journal
Journal of Biological Chemistry, Vol. 271, No. 30, pp. 17966–17973
Publisher
Elsevier
Publication Date
July 1996
DOI
10.1074/jbc.271.30.17966
ISSN
0021-9258
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptation, PhysiologicalBacterial Physiological PhenomenaBacterial ProteinsChemoreceptor CellsChemotaxisEnzyme ActivationEscherichia coli ProteinsHistidine KinaseMembrane ProteinsMethyl-Accepting Chemotaxis ProteinsProtein BindingProtein FoldingProtein Kinase InhibitorsProtein Structure, TertiaryReceptors, Cell SurfaceSignal Transduction