Journal article
GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R
Abstract
Obesity and diabetes are characterized by increased inflammation reflecting disordered control of innate immunity. We reveal a local intestinal intraepithelial lymphocyte (IEL)-GLP-1 receptor (GLP-1R) signaling network that controls mucosal immune responses. Glp1r expression was enriched in intestinal IEL preparations and copurified with markers of Tαβ and Tγδ IELs, the two main subsets of intestinal IELs. Exendin-4 increased cAMP accumulation …
Authors
Yusta B; Baggio LL; Koehler J; Holland D; Cao X; Pinnell LJ; Johnson-Henry KC; Yeung W; Surette MG; Bang KWA
Journal
Diabetes, Vol. 64, No. 7, pp. 2537–2549
Publisher
American Diabetes Association
Publication Date
July 1, 2015
DOI
10.2337/db14-1577
ISSN
0012-1797