Journal article
Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain
Abstract
Bipolar disorder is a chronic and severe mental disorder. Recently, new animal models have emerged to further investigate underlying mechanisms of bipolar disorder such as ouabain-induced hyperactivity in rats. In this study, we investigated the cerebrospinal fluid levels of S100B protein as a putative marker of astrocytic activity in bipolar mania induced by intracerebroventricular administration of ouabain in rats. Ouabain induced a two-fold …
Authors
Machado-Vieira R; Schmidt AP; Ávila TT; Kapczinski F; Soares JC; Souza DO; Portela LVC
Journal
Life Sciences, Vol. 76, No. 7, pp. 805–811
Publisher
Elsevier
Publication Date
December 2004
DOI
10.1016/j.lfs.2004.07.021
ISSN
0024-3205