Journal article
Evidence of astrogliosis in rat hippocampus after d-amphetamine exposure
Abstract
INTRODUCTION: Psychostimulants such as amphetamine (AMPH) induce manic-like symptoms in humans and studies have suggested that bipolar disorder (BD) may be associated to dopamine dysfunction. Glial fibrillary acidic protein (GFAP) up-regulation is considered a marker of astrogliosis, and it has been associated to behavioral sensitization.
PURPOSE: We aimed to investigate the behavioral effects of acute and chronic AMPH on rat locomotion and …
Authors
Frey BN; Andreazza AC; Ceresér KM; Martins MR; Petronilho FC; de Souza DF; Tramontina F; Gonçalves CA; Quevedo J; Kapczinski F
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 30, No. 7, pp. 1231–1234
Publisher
Elsevier
Publication Date
September 2006
DOI
10.1016/j.pnpbp.2006.03.016
ISSN
0278-5846
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
Analysis of VarianceAnimalsAstrocytesBehavior, AnimalCentral Nervous System StimulantsCerebral CortexDextroamphetamineDose-Response Relationship, DrugDrug Administration ScheduleEnzyme-Linked Immunosorbent AssayGene ExpressionGlial Fibrillary Acidic ProteinHippocampusImmunohistochemistryMaleMotor ActivityRatsRats, Wistar