Journal article
Lithium increases nerve growth factor levels in the rat hippocampus in an animal model of mania
Abstract
Pharmacological studies suggest that neurotrophins may play a role in the effects of lithium and valproate on mood regulation. In this study, we tested the hypotheses that lithium and valproate would reverse and prevent the behavioral and biochemical effects of amphetamine, using a rat model of mania. In the reversal treatment, male Wistar rats were first administered D-amphetamine or saline for 14 days, and then, between days 8-14, rats were …
Authors
Frey BN; Andreazza AC; Rosa AR; Martins MR; Valvassori SS; Réus GZ; Hatch JP; Quevedo J; Kapczinski F
Journal
Behavioural Pharmacology, Vol. 17, No. 4, pp. 311–318
Publisher
Wolters Kluwer
Publication Date
6 2006
DOI
10.1097/01.fbp.0000205013.59455.09
ISSN
0955-8810