Journal article
Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels
Abstract
The non-competitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist ketamine has been shown to produce cognitive deficits. However, the effects of ketamine on the consolidation phase of memory remain poorly characterized. Here we show that systemic administration of ketamine immediately after training dose-dependently impairs long-term retention of memory for a novel object recognition (NOR) task in rats. Control experiments showed …
Authors
Goulart BK; de Lima MNM; de Farias CB; Reolon GK; Almeida VR; Quevedo J; Kapczinski F; Schröder N; Roesler R
Journal
Neuroscience, Vol. 167, No. 4, pp. 969–973
Publisher
Elsevier
Publication Date
6 2010
DOI
10.1016/j.neuroscience.2010.03.032
ISSN
0306-4522