Journal article
The Effects of a Monoclonal Antibody Directed against Tumor Necrosis Factor-α in Asthma
Abstract
RATIONALE: Neutralization of tumor necrosis factor-alpha (TNF-alpha) is an effective antiinflammatory therapy for several chronic inflammatory diseases.
METHODS AND OBJECTIVES: We undertook a double-blind, placebo-controlled, parallel-group design study in 38 patients with moderate asthma treated with inhaled corticosteroids but symptomatic during a run-in phase. Infliximab (5 mg/kg) or placebo was administered by intravenous infusion at Weeks …
Authors
Erin EM; Leaker BR; Nicholson GC; Tan AJ; Green LM; Neighbour H; Zacharasiewicz AS; Turner J; Barnathan ES; Kon OM
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 174, No. 7, pp. 753–762
Publisher
American Thoracic Society
Publication Date
October 1, 2006
DOI
10.1164/rccm.200601-072oc
ISSN
1073-449X