Journal article
Common β‐lactamases inhibit bacterial biofilm formation
Abstract
Beta-lactamases, which evolved from bacterial penicillin-binding proteins (PBPs) involved in peptidoglycan (PG) synthesis, confer resistance to beta-lactam antibiotics. While investigating the genetic basis of biofilm development by Pseudomonas aeruginosa, we noted that plasmid vectors encoding the common beta-lactamase marker TEM-1 caused defects in twitching motility (mediated by type IV pili), adherence and biofilm formation without …
Authors
Gallant CV; Daniels C; Leung JM; Ghosh AS; Young KD; Kotra LP; Burrows LL
Journal
Molecular Microbiology, Vol. 58, No. 4, pp. 1012–1024
Publisher
Wiley
Publication Date
November 2005
DOI
10.1111/j.1365-2958.2005.04892.x
ISSN
0950-382X