Journal article
Association of renin–angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension: prospective cohort study
Abstract
OBJECTIVE: The renin-angiotensin system and endothelial function have both been associated with hypertension. The aim of the present study was to assess the relationship of six previously characterized gene variants in the renin-angiotensin system and the NOS3 gene with blood pressure progression and incident hypertension.
METHODS: We analyzed data from 18 436 Caucasian women who participated in a prospective cohort study and were free of …
Authors
Conen D; Glynn RJ; Buring JE; Ridker PM; Zee RY
Journal
Journal of Hypertension, Vol. 26, No. 9, pp. 1780–1786
Publisher
Wolters Kluwer
Publication Date
September 2008
DOI
10.1097/hjh.0b013e3283077eef
ISSN
0263-6352
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AngiotensinogenAntioxidantsAspirinBlood PressureCyclooxygenase InhibitorsDisease ProgressionFemaleGene FrequencyGenetic Predisposition to DiseaseHaplotypesHumansHypertension, RenalIncidenceMiddle AgedNitric Oxide Synthase Type IIIPeptidyl-Dipeptidase APolymorphism, Single NucleotideProspective StudiesReceptor, Angiotensin, Type 1Renin-Angiotensin SystemRisk FactorsVitamin E