Journal article
The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut–brain communication
Abstract
BACKGROUND: The probiotic Bifidobacterium longum NCC3001 normalizes anxiety-like behavior and hippocampal brain derived neurotrophic factor (BDNF) in mice with infectious colitis. Using a model of chemical colitis we test whether the anxiolytic effect of B. longum involves vagal integrity, and changes in neural cell function. Methods Mice received dextran sodium sulfate (DSS, 3%) in drinking water during three 1-week cycles. Bifidobacterium …
Authors
Bercik P; Park AJ; Sinclair D; Khoshdel A; Lu J; Huang X; Deng Y; Blennerhassett PA; Fahnestock M; Moine D
Journal
Neurogastroenterology & Motility, Vol. 23, No. 12, pp. 1132–1139
Publisher
Wiley
Publication Date
December 2011
DOI
10.1111/j.1365-2982.2011.01796.x
ISSN
1350-1925