Journal article
Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: A small-angle neutron scattering and fluorescence study
Abstract
In response to apoptotic stimuli, the pro-apoptotic protein Bax inserts in the outer mitochondrial membrane, resulting in the formation of pores and the release of several mitochondrial components, and sealing the cell's fate. To study the binding of Bax to membranes, we used an in vitro system consisting of 50nm diameter liposomes prepared with a lipid composition mimicking that of mitochondrial membranes in which recombinant purified …
Authors
Satsoura D; Kučerka N; Shivakumar S; Pencer J; Griffiths C; Leber B; Andrews DW; Katsaras J; Fradin C
Journal
Biochimica et Biophysica Acta, Vol. 1818, No. 3, pp. 384–401
Publisher
Elsevier
Publication Date
March 2012
DOI
10.1016/j.bbamem.2011.10.007
ISSN
0006-3002