Coffee increases antioxidant enzyme capacity in the brain of male G93A mice, an animal model of amyotrophic lateral sclerosis (ALS)

Oxidative stress is implicated in several neurodegenerative diseases including ALS. Coffee (COF) consumption increases antioxidant status and reduces oxidative stress. To determine whether this effect is due to its single or combined constituents, we studied the effect of COF, caffeine (CAF) and chlorogenic acid (CHLA) on food intake (FI), body weight (BW), body condition (BC), motor performance (MP), ability to move (AM), clinical score (CS), …