Long‐term caloric restriction increases lipid peroxidation, but decreases protein oxidation, in the skeletal muscle of the Cu/Zn‐SOD mutant G93A mouse, an animal model of ALS

We previously reported that long‐term caloric restriction (CR) improves motor performance but hastens clinical onset, disease progression and endpoint in the G93A mouse, an animal model of amyotrophic lateral sclerosis (ALS) (Hamadeh et al, 2005). We hypothesized that CR would increase oxidative stress, basal levels of which are heightened in this animal model, partly due to a decrease or no change in most antioxidant enzyme activity. Starting …